Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties

Aseptic loosening and bacterial infections are the two main causes of failure for metallic implants used joint replacement. A coating that is both bioactive possesses antimicrobial properties may address such shortcomings improve performance implant. We have sought to study combining hydroxyapatite-based nanoparticles or coatings with baicalein, a plant-extracted molecule antibacterial antioxidant properties. (B-type) carbonated hydroxyapatite prepared by chemical wet method could subsequently adsorbed soaking in baicalein solution. The amount was determined be 63 mg.g?1 thermogravimetric measurements. In second approach, on biomimetic calcium-deficient planar (12 ?m thick) deposited Ti6Al4V alloy from an aqueous solution calcium, phosphate, sodium magnesium salts. Soaking coated titanium induced partial dissolution/remodeling upper surface coating. However, observed remodeling much more pronounced presence solution, compared pure water. HAp layer, although it not precisely quantified, assessed XPS fluorescence analysis. Planar exhibited significant against Staphylococcus epidermidis. Baicalein-modified These results illustrate potential as carrier natural biologically-active molecules also discuss challenges associated their applications agents.